A Prospective Study of Acute Kidney Injury According to KDIGO Definition and its Mortality Predictors.

BACKGROUND Acute kidney injury is no longer considered to be an innocent bystander merely reflecting co-existent pathologies but an independent risk factor for mortality in the ICU. AIMS AND OBJECTIVES To study clinical profile and correlation of patients with acute kidney injury (AKI) according to KDIGO definition with respect to incidence, outcome and different causes of AKI in critical care unit. STUDY DESIGN AND SETTING It is a prospective observational study; and was carried out in the ICU of a tertiary care, teaching, public hospital. MATERIAL AND METHODS We studied 316 patients developing AKI in ICU over a period of 1 year. RESULTS AND CONCLUSION Incidence of AKI in our ICU was 37.71% and mortality rate was 51.9%. Tropical Acute febrile illnesses followed by sepsis were the most common causes of AKI in ICU. Most common cause of AKI among tropical acute febrile illnesses (AFI) was malaria and among sepsis group was lung infection. In our study KDIGO staging could not predict outcome because majority of patients had multisystem failure. Pre-existing co-morbidities, multi-organ system failure were associated with high mortality. APACHE II scoring system under- predicted the mortality in patients with AKI.